Effects of Developmental Nicotine Exposure on Frontal Cortical GABA-to-Non-GABA Neuron Ratio and Novelty-Seeking Behavior
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چکیده
منابع مشابه
Non-cholinergic effects of paraoxon on [3h]-GABA release from rat cerebellar giant synaptosomes
Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evidences indicate that OPs affect the GABA system via noncholinergic mechanisms. The purpose of this study was to investigate the effects of paraoxon on K+-evoked [3H]-GABA release from cerebellar synaptosomes. Adult male rats (200 ± 30 g; 3-4 months old) were sacrificed by decapitation and the cerebel...
متن کاملNon-cholinergic effects of paraoxon on [3h]-GABA release from rat cerebellar giant synaptosomes
Diethyl p-nitrophenyl phosphate (paraoxon) is the active toxic metabolite of parathion. Some evidences indicate that OPs affect the GABA system via noncholinergic mechanisms. The purpose of this study was to investigate the effects of paraoxon on K+-evoked [3H]-GABA release from cerebellar synaptosomes. Adult male rats (200 ± 30 g; 3-4 months old) were sacrificed by decapitation and the cerebel...
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Functional neuroimaging metrics are thought to reflect changes in neurotransmitter flux, but changes in neurotransmitter levels have not been demonstrated in humans during a cognitive task, and the relationship between neurotransmitter dynamics and hemodynamic activity during cognition has not yet been established. We evaluate the concentration of the major inhibitory (GABA) and excitatory (glu...
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Cortical networks spontaneously fluctuate between persistently active Up states and quiescent Down states. The Up states are maintained by recurrent excitation within local circuits, and can be turned on and off by synaptic input. GABAergic inhibition is believed to be important for stabilizing such persistent activity by balancing the excitation, and could have an additional role in terminatin...
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ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2019
ISSN: 1047-3211,1460-2199
DOI: 10.1093/cercor/bhz207